Description

5-Bromo-7-Fluorochroman-4-One is a high-purity fluorinated and brominated chromanone derivative, serving as a critical advanced intermediate in modern organic synthesis. Its unique halogenated structure makes it a valuable building block for constructing complex molecules with tailored properties. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the creation of novel herbicides and fungicides, leveraging its halogenated ring system for bioactivity.
• Material Science Research: Serves as a precursor for the synthesis of specialized organic electronic materials and liquid crystals.
• Chemical Biology Probes: Employed in the design of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring halogenated chroman scaffolds.

Basic Information

Product Name	5-Bromo-7-Fluorochroman-4-One
CAS No.	1260008-29-4
Molecular Formula	C9H6BrFO2
Molecular Weight	245.05 g/mol
Synonyms	5-Bromo-7-fluoro-4-chromanone; 4H-1-Benzopyran-4-one, 5-bromo-7-fluoro-2,3-dihydro-; 7-Fluoro-5-bromochroman-4-one; 2,3-Dihydro-5-bromo-7-fluoro-4H-1-benzopyran-4-one; 5-Bromo-7-fluoro-3,4-dihydro-2H-1-benzopyran-4-one
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-7-Fluorochroman-4-One is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after initial use to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.