Description

n-(4-Fluorobenzyl)-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-value, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is critical for research and development in medicinal chemistry, particularly in the construction of complex molecules through Suzuki-Miyaura cross-coupling reactions. It is primarily sought after by pharmaceutical R&D laboratories, agrochemical manufacturers, and fine chemical producers for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, especially in oncology and CNS research.
• Suzuki-Miyaura Cross-Coupling: The boronic ester pinacol group serves as a crucial handle for forming carbon-carbon bonds with aryl halides, enabling the synthesis of complex biaryl structures.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides requiring specific fluorinated aromatic motifs.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where its structure can influence charge transport properties.
• Ligand and Catalyst Development: The aniline and fluorobenzyl groups make it a potential precursor for creating novel ligands used in catalytic systems.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific, functionalized aromatic boronic esters.

Basic Information

Product Name	n-(4-Fluorobenzyl)-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	1259285-58-9
Molecular Formula	C19H23BFNO2
Molecular Weight	327.20 g/mol
Synonyms	2-((4-Fluorobenzyl)amino)phenylboronic acid pinacol ester; 2-Amino-N-(4-fluorobenzyl)benzeneboronic acid pinacol ester; 1-(4-Fluorobenzylamino)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; N1-(4-Fluorobenzyl)benzene-1,2-diamine boronic acid pinacol ester; B-[2-[(4-Fluorophenyl)methyl]amino]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1259285-58-9; Aniline, N-[(4-fluorophenyl)methyl]-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Our n-(4-Fluorobenzyl)-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to maintain stability. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.