Description

5-(2-(Trifluoromethoxy)Phenyl)Pyridin-3-Amine CAS NO 1258620-51-7 is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethoxy-substituted aromatic scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the development of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. Industrial and research chemists in the pharmaceutical, agrochemical, and advanced materials sectors need it for the synthesis of targeted molecules, particularly in drug discovery programs for central nervous system (CNS) and inflammatory diseases.

Application

• Key synthetic intermediate in the research and development of new small molecule pharmaceuticals, especially for CNS targets.
• Building block for constructing trifluoromethoxy-containing bioactive compounds in agrochemicals, such as herbicides and fungicides.
• Precursor in the synthesis of ligands for catalysis and functional materials due to its electron-deficient aromatic system.
• Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Valuable starting material for custom synthesis and contract research organizations (CROs) serving the life sciences industry.
• Intermediate in the development of diagnostic agents and radiopharmaceuticals where the trifluoromethoxy group is utilized as a stable label.

Basic Information

Product Name	5-(2-(Trifluoromethoxy)Phenyl)Pyridin-3-Amine
CAS No.	1258620-51-7
Molecular Formula	C12H9F3N2O
Molecular Weight	254.21 g/mol
Synonyms	3-Amino-5-[2-(trifluoromethoxy)phenyl]pyridine; 5-[2-(Trifluoromethoxy)phenyl]pyridin-3-amine; 5-(2-Trifluoromethoxyphenyl)pyridin-3-ylamine; 3-Pyridinamine, 5-[2-(trifluoromethoxy)phenyl]-; 1258620-51-7; 5-(2-(Trifluoromethoxy)phenyl)-3-pyridinamine
EINECS	Contact for details

Quality Control

Every batch of 5-(2-(Trifluoromethoxy)Phenyl)Pyridin-3-Amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and pharmaceutical development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and MS are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.