Description

cis-2-Fluorocyclopropanecarboxamide is a high-value fluorinated cyclopropane derivative, a key building block in modern synthetic chemistry. Its unique strained-ring structure combined with fluorine substitution makes it a critical intermediate for developing novel pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. This compound is essential for medicinal chemistry researchers and process development chemists in the pharmaceutical and crop protection industries seeking to incorporate the cyclopropane motif into new active molecules.

Application

• Pharmaceutical Intermediate: A versatile synthon for the synthesis of fluorinated drug candidates, particularly in protease inhibitors, kinase inhibitors, and CNS-active compounds.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides where the fluorocyclopropane unit can improve potency and environmental profile.
• Medicinal Chemistry: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Biology: Employed as a probe or labeled compound to study enzyme mechanisms and biological pathways due to its fluorine atom.
• Process Chemistry: Used in route scouting and scale-up synthesis for the commercial production of active pharmaceutical ingredients (APIs).
• Material Science Precursor: Potential intermediate for synthesizing specialized fluorinated polymers or liquid crystals with unique properties.

Basic Information

Product Name	cis-2-Fluorocyclopropanecarboxamide
CAS No.	1258298-41-7
Molecular Formula	C4H6FNO
Molecular Weight	103.10 g/mol
Synonyms	2-Fluorocyclopropanecarboxamide, cis-; cis-2-Fluorocyclopropane-1-carboxamide; (1R,2S)-2-Fluorocyclopropanecarboxamide; (1S,2R)-2-Fluorocyclopropanecarboxamide; 2-Fluoro-cyclopropanecarboxylic acid amide; FC-CA; Fluorocyclopropanecarboxamide
EINECS	Contact for details

Quality Control

Every batch of cis-2-Fluorocyclopropanecarboxamide is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, which include data from NMR, HPLC, and MS. Our quality commitment aligns with cGMP standards for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
cis-Isomer Content (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.