Description

(1R,2R,6S,8R)-4-(4-Methoxyphenyl)-2,9,9-Trimethyl-3,5-Dioxa-4-Boratricyclo[6.1.1.06]Decane is a sophisticated, chiral organoboron compound featuring a unique tricyclic structure, serving as a high-value synthetic intermediate and ligand precursor. Its precise stereochemistry and boronate ester functionality make it a critical building block for the development of novel pharmaceuticals, agrochemicals, and advanced materials. This compound is essential for research and development chemists in fine chemical synthesis, particularly for applications in asymmetric catalysis, cross-coupling reactions, and the construction of complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Asymmetric Catalysis Ligand: Used to develop novel chiral ligands and catalysts for enantioselective synthesis, enhancing the efficiency of producing single-isomer compounds.
• Agrochemical Synthesis: Building block for creating advanced, stereochemically defined pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where precise molecular structure dictates performance.
• Cross-Coupling Reactions: Acts as an organoboron reagent (e.g., in Suzuki-Miyaura couplings) for the formation of carbon-carbon bonds in complex molecule assembly.
• Academic & Industrial R&D: Serves as a valuable tool compound for methodological development in organic and organometallic chemistry laboratories.

Basic Information

Product Name	(1R,2R,6S,8R)-4-(4-Methoxyphenyl)-2,9,9-Trimethyl-3,5-Dioxa-4-Boratricyclo[6.1.1.06]Decane
CAS No.	1258238-86-6
Molecular Formula	C18H25BO3
Molecular Weight	300.20 g/mol
Synonyms	4-(4-Methoxyphenyl)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decane, (1R,2R,6S,8R)-rel-; (1R,2R,6S,8R)-4-(p-Methoxyphenyl)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decane; Chiral Pinanediol (4-Methoxyphenyl)boronate; (4-Methoxyphenyl)boronic acid pinanediol ester; (R,R)-Pinanediol (4-Methoxyphenyl)boronate; (1R,2R,6S,8R)-4-(4-Methoxyphenyl)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]decane
EINECS	Contact for details

Quality Control

Our production of this high-purity organoboron compound adheres to strict quality management systems. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure excellent chemical and enantiomeric purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.