Description

1-((1S,4S)-4-(tert-Butyldimethylsilyloxy)Cyclohexyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functionality. This compound is critically important as a key building block in modern medicinal chemistry, enabling efficient Suzuki-Miyaura cross-coupling reactions for the synthesis of complex bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for clinical candidates.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group enables efficient carbon-carbon bond formation with aryl/heteroaryl halides under palladium catalysis.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and library synthesis for creating diverse compound sets targeting various biological pathways.
• Process Chemistry & Scale-Up: Employed in route development and kilogram-scale production for pre-clinical and early-phase clinical material.
• Chemical Biology Probe Development: Utilized for constructing molecules used to study protein function and cellular mechanisms.
• Agrochemical Research: Potential application in the synthesis of novel crop protection agents requiring specific heterocyclic architectures.

Basic Information

Item	Detail
Product Name	1-((1S,4S)-4-(tert-Butyldimethylsilyloxy)Cyclohexyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1257997-17-3
Molecular Formula	C21H39BN2O3Si
Molecular Weight	406.45 g/mol
Synonyms	(1S,4S)-4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)cyclohexyl tert-butyldimethylsilyl ether; 1-[(1S,4S)-4-[[tert-Butyl(dimethyl)silyl]oxy]cyclohexyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; (1S,4S)-4-(4-(Pinacolboranyl)-1H-pyrazol-1-yl)cyclohexyl tert-butyldimethylsilyl ether; TBS-protected Cyclohexyl Pyrazole Boronic Ester; (S,S)-TBDMS Cyclohexylpyrazole Pinacol Boronate; CAS 1257997-17-3; Pharmaceutical Intermediate 1257997-17-3
EINECS	Contact for details

Quality Control

Our production of 1-((1S,4S)-4-(tert-Butyldimethylsilyloxy)Cyclohexyl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for sensitive pharmaceutical applications. All material is characterized by advanced analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere (e.g., nitrogen or argon) to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.