Description

2-Bromomethylphenylboronic Acid Mida Ester is a versatile and highly valuable organoboron building block, specifically designed for advanced cross-coupling reactions. Its core value lies in the MIDA (N-methyliminodiacetic acid) ester protecting group, which stabilizes the boronic acid moiety, enhancing its shelf-life and handling properties for complex multi-step syntheses. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require reliable, high-purity intermediates for constructing complex molecular architectures, particularly in Suzuki-Miyaura couplings.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for creating biaryl and heterobiaryl structures common in drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific phenyl-substituted frameworks.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs, where precise molecular structure is critical.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling reactions due to the stability and controlled reactivity of the MIDA-protected boronate.
• Chemical Biology & Probe Development: Serves as a precursor for synthesizing molecular probes and tags used in bio-conjugation and imaging studies.
• Process Chemistry & Scale-up: The stabilized form is ideal for multi-step synthetic sequences in process development, offering improved handling and purification compared to the free boronic acid.

Basic Information

Product Name	2-Bromomethylphenylboronic Acid Mida Ester
CAS No.	1257740-52-5
Molecular Formula	C₁₂H₁₃BBrNO₄
Molecular Weight	326.95 g/mol
Synonyms	2-(Bromomethyl)benzeneboronic acid MIDA ester; (2-(Bromomethyl)phenyl)boronic acid MIDA ester; N-Methyliminodiacetic acid (2-(bromomethyl)phenyl)boronate; Boronic acid, B-(2-(bromomethyl)phenyl)-, N-methyliminodiacetic acid ester; MIDA boronate of 2-bromomethylphenylboronic acid; 2-Bromobenzylboronic acid MIDA ester
EINECS	Contact for details

Quality Control

Our 2-Bromomethylphenylboronic Acid Mida Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.