Description

1H-Benzo[D][1,2,3]Triazol-5-Ylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry, particularly in metal-catalyzed cross-coupling reactions. Its primary value lies in enabling the efficient and selective construction of complex heterocyclic scaffolds, which are critical in advanced material and pharmaceutical research. This compound is a key building block for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for drug discovery and development programs.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A crucial reagent for forming carbon-carbon bonds between the benzotriazole moiety and various aryl or heteroaryl halides, enabling the synthesis of complex biaryl structures.
• Pharmaceutical Intermediate Synthesis: Serves as a versatile building block in the research and development of active pharmaceutical ingredients (APIs), especially those containing fused benzotriazole heterocycles.
• Agrochemical Research: Used in the discovery and synthesis of novel herbicides, fungicides, and insecticides that leverage the benzotriazole pharmacophore.
• Material Science & Organic Electronics: A precursor for creating organic semiconductors, ligands for metal-organic frameworks (MOFs), and photoactive materials due to its electron-deficient aromatic system.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes and enzyme inhibition.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for drug discovery campaigns in medicinal chemistry.

Basic Information

Product Name	1H-Benzo[D][1,2,3]Triazol-5-Ylboronic Acid Pinacol Ester
CAS No.	1257651-13-0
Molecular Formula	C14H18BN3O2
Molecular Weight	271.13 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d][1,2,3]triazole; 1H-Benzotriazol-5-ylboronic Acid Pinacol Ester; Benzo[1,2,3]triazol-5-ylboronic Acid Pinacol Ester; 5-(Pinacolatoboryl)-1H-benzo[d][1,2,3]triazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzotriazole; BTZ-BPin; Benzotriazole-5-boronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 1H-Benzo[D][1,2,3]Triazol-5-Ylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation. For long-term storage, consider storing under an inert gas blanket.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.