Description

2-Carboxyphenylboronic Acid Dihydrate is a multifunctional organoboron compound that serves as a valuable bifunctional building block in synthetic chemistry. Its dual functionality, combining a boronic acid group and a carboxylic acid group on the same aromatic ring, makes it a critical reagent for constructing complex molecular architectures. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for applications such as Suzuki-Miyaura cross-coupling and the synthesis of bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via cross-coupling reactions, particularly for creating biaryl and heterobiaryl structures.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific aromatic carboxylic acid motifs.
• Material Science: Serves as a monomer or linker for constructing metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and functional polymers.
• Chemical Biology & Proteomics: Employed in the design and synthesis of enzyme inhibitors, molecular probes, and bioconjugation reagents.
• Ligand Synthesis: Acts as a starting material for preparing bidentate and tridentate ligands used in catalysis and metal complexation.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic synthesis and medicinal chemistry research programs.

Basic Information

Product Name	2-Carboxyphenylboronic Acid Dihydrate
CAS No.	1257650-88-6
Molecular Formula	C7H7BO4 · 2H2O
Molecular Weight	199.95 g/mol (anhydrous basis)
Synonyms	(2-Carboxyphenyl)boronic acid dihydrate; 2-Boronobenzoic acid dihydrate; o-Carboxybenzeneboronic acid dihydrate; 2-Carboxybenzeneboronic Acid Dihydrate; Benzoic acid, 2-borono-, dihydrate; 2-Boronobenzene-1-carboxylic acid dihydrate; B-(2-Carboxyphenyl)boronic acid dihydrate; 2-Carboxy Phenyl Boronic Acid Dihydrate
EINECS	Contact for details

Quality Control

Our 2-Carboxyphenylboronic Acid Dihydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture, which may affect purity and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	16.0% - 18.5% (theoretical for dihydrate: ~18.0%)
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.