Description

3-(1,3-Dioxolan-2-Yl)Phenylboronic Acid Pinacol Ester is a high-value, protected boronic acid ester derivative, serving as a crucial synthetic intermediate in advanced organic chemistry. Its primary value lies in providing a stable, reactive handle for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it facilitates the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science: Employed in the creation of organic electronic materials, such as those for OLEDs and organic photovoltaics, where precise molecular architecture is critical.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the global life sciences industry.

Basic Information

Product Name	3-(1,3-Dioxolan-2-Yl)Phenylboronic Acid Pinacol Ester
CAS No.	1257648-34-2
Molecular Formula	C15H21BO4
Molecular Weight	276.14 g/mol
Synonyms	[3-(1,3-Dioxolan-2-yl)phenyl]boronic acid pinacol ester; 2-[3-(1,3-Dioxolan-2-yl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-(1,3-Dioxolan-2-yl)benzeneboronic acid pinacol ester; Pinacol [3-(1,3-dioxolan-2-yl)phenyl]boronate; 3-(1,3-Dioxolan-2-yl)phenylboronic acid, pinacol ester; Boronic acid, B-[3-(1,3-dioxolan-2-yl)phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 3-(1,3-Dioxolan-2-Yl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), identity (NMR/IR), and impurity profiles. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and prevent hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.