Description

3-Bromo-2-Fluorophenylboronic Acid Mida Ester is a high-value, protected boronic acid derivative designed for advanced synthetic chemistry. This compound is crucial for enabling robust and selective cross-coupling reactions, particularly in the synthesis of complex pharmaceutical intermediates and agrochemicals. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable building blocks for Suzuki-Miyaura and other palladium-catalyzed couplings.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing complex biaryl and heterobiaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Research & Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring specific halogenated phenyl motifs.
• Material Science: Serves as a monomer or precursor in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Cross-Coupling Reactions: Specifically engineered for use in Suzuki-Miyaura couplings, offering enhanced stability and reduced protodeboronation compared to the corresponding free boronic acid.
• Medicinal Chemistry & Drug Discovery: Enables efficient library synthesis for structure-activity relationship (SAR) studies due to its robust handling characteristics.
• Chemical Biology: Can be utilized as a probe or linker in bioconjugation chemistry and the development of chemical tools.

Basic Information

Product Name	3-Bromo-2-Fluorophenylboronic Acid Mida Ester
CAS No.	1257647-82-7
Molecular Formula	C₁₁H₁₀BBrFNO₃
Molecular Weight	314.92 g/mol
Synonyms	3-Bromo-2-fluorophenylboronic acid MIDA ester; N-Methyliminodiacetic acid (3-bromo-2-fluorophenyl)boronate; (3-Bromo-2-fluorophenyl)-4,6,10-trioxa-5-bora-2-azadodec-5-en-12-oic acid; MIDA Boronate of 3-Bromo-2-fluorophenylboronic acid; 3-Bromo-2-fluoro-MIDA-boronate; B-(3-Bromo-2-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane-4,6-dione analog (MIDA); Boronic acid, B-(3-bromo-2-fluorophenyl)-, 2,2'-(methylimino)diethanol ester
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Fluorophenylboronic Acid Mida Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced techniques including NMR (¹H, ¹³C, ¹¹B), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.