Description

3-(n-Boc-Aminomethyl)Pyridine-5-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block designed for advanced pharmaceutical and agrochemical research. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to accelerate the discovery and synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing pyridine and biaryl motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation, enabling the construction of complex molecular architectures.
• Medicinal Chemistry & SAR Studies: Used in parallel and combinatorial synthesis to rapidly generate libraries of compounds for structure-activity relationship (SAR) optimization.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides that require specific heterocyclic frameworks.
• Material Science Research: Potential precursor for creating organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the scalable, cost-effective manufacturing of target molecules.

Basic Information

Product Name	3-(n-Boc-Aminomethyl)Pyridine-5-Boronic Acid Pinacol Ester
CAS No.	1257554-93-0
Molecular Formula	C18H29BN2O4
Molecular Weight	348.25 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(((tert-butoxycarbonyl)amino)methyl)pyridine; 3-((tert-Butoxycarbonylamino)methyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-(Boc-aminomethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-((Boc-amino)methyl)pyridine-5-boronic acid pinacol ester; 3-(N-Boc-aminomethyl)pyridin-5-ylboronic acid pinacol ester; tert-Butyl N-[[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]methyl]carbamate; BOC-AMINOMETHYL-PYRIDINE-5-BORONIC ACID PINACOL ESTER
EINECS	Contact for details

Quality Control

Our 3-(n-Boc-Aminomethyl)Pyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting critical specifications. Our quality commitment aligns with the standards required for GMP intermediates and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is light-sensitive and easily oxidized; prolonged exposure to air, light, or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.