Description

2H-Pyrrolo[2,3-B]Pyridin-2-One, 1,3-Dihydro-1,3,3-Trimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a valuable pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. It is primarily utilized by research organizations and pharmaceutical developers engaged in the synthesis of novel small-molecule therapeutics, particularly in oncology and CNS drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new active pharmaceutical ingredients (APIs).
• Suzuki-Miyaura Cross-Coupling: Enables the formation of carbon-carbon bonds to attach complex aromatic and heteroaromatic fragments.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and library synthesis to explore structure-activity relationships (SAR).
• Process Chemistry Development: Serves as a critical reagent in scaling up synthetic routes from laboratory to pilot plant scale.
• Chemical Biology Probes: Can be incorporated into molecules designed to study biological pathways and protein functions.
• Agrochemical Research: Potential intermediate in the synthesis of novel crop protection agents with complex heterocyclic structures.
• Material Science: Used in the synthesis of organic electronic materials and ligands for catalysts.

Basic Information

Product Name	2H-Pyrrolo[2,3-B]Pyridin-2-One, 1,3-Dihydro-1,3,3-Trimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1257554-80-5
Molecular Formula	C16H25BN2O3
Molecular Weight	304.20 g/mol
Synonyms	1,3-Dihydro-1,3,3-trimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-pyrrolo[2,3-b]pyridin-2-one; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3,3-trimethyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 1,3,3-Trimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one; 2H-Pyrrolo[2,3-b]pyridin-2-one, 1,3-dihydro-1,3,3-trimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-Boronic acid pinacol ester of 1,3,3-trimethyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one
EINECS	Contact for details

Quality Control

Our 2H-Pyrrolo[2,3-B]Pyridin-2-One, 1,3-Dihydro-1,3,3-Trimethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive coupling reactions. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.