Description

3-(Difluoromethoxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value organoboron building block, specifically a pyridine boronic ester, designed for advanced synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process R&D teams developing novel active ingredients, particularly in the areas of small molecule drug discovery and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing difluoromethoxy and pyridine motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic architectures.
• Material Science Research: Serves as a precursor for creating functionalized organic materials, such as ligands for catalysts or components for organic electronics.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a coupling partner with aryl or vinyl halides to form biaryl or styryl compounds under palladium catalysis.
• Medicinal Chemistry Library Synthesis: Enables the rapid, parallel construction of diverse compound libraries for high-throughput screening in drug discovery programs.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable manufacturing of target molecules.

Basic Information

Item	Details
Product Name	3-(Difluoromethoxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1257554-65-6
Molecular Formula	C13H18BF2NO3
Molecular Weight	285.10 g/mol
Synonyms	5-(Difluoromethoxy)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine; 3-Difluoromethoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3-(difluoromethoxy)pyridine; Pinacol 3-(Difluoromethoxy)-5-pyridylboronate; 3-(Difluoromethoxy)pyridine-5-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance in coupling reactions. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.