Description

3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-imidazo[4,5-b]pyridine CAS NO 1257554-02-1 is a high-value, heterocyclic boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used to create novel herbicide and fungicide candidates by introducing the imidazopyridine-boronate moiety into lead structures.
• Material Science: Building block for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated system.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and activity-based protein profiling (ABPP) reagents.
• Cross-Coupling Reactions: A specialized reagent for Suzuki-Miyaura cross-coupling to form carbon-carbon bonds under mild conditions.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Item	Details
Product Name	3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-imidazo[4,5-b]pyridine
CAS No.	1257554-02-1
Molecular Formula	C15H22BN3O2
Molecular Weight	287.17 g/mol
Synonyms	3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazo[4,5-b]pyridine; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methyl-3H-imidazo[4,5-b]pyridine; 3-Methylimidazo[4,5-b]pyridine-6-boronic acid pinacol ester; 6-Borono-3-methyl-3H-imidazo[4,5-b]pyridine pinacol ester; 3-Methyl-6-(pinacolboranyl)imidazo[4,5-b]pyridine; 1257554-02-1; Pinacol 3-methylimidazo[4,5-b]pyridine-6-boronate
EINECS	Contact for details

Quality Control

Our 3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3H-imidazo[4,5-b]pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage and when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.