Description

1-Methyl-1H-Indazole-4-Boronic Acid Hydrochloride is a high-purity boronic acid derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced material synthesis. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries, where it is used to construct complex molecular architectures for new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to create advanced active ingredients for crop protection and pest management solutions.
• Material Science: Serves as a monomer or functionalizing agent in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Synthesis: A versatile reagent for Suzuki-Miyaura cross-coupling reactions to form biaryl and heterobiaryl structures.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and discovery chemistry projects.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	1-Methyl-1H-Indazole-4-Boronic Acid Hydrochloride
CAS No.	1257527-53-9
Molecular Formula	C8H10BN2O2 • HCl
Molecular Weight	212.45 g/mol (Free acid)
Synonyms	1-Methyl-1H-indazol-4-ylboronic acid hydrochloride; 4-Borono-1-methyl-1H-indazole hydrochloride; (1-Methyl-1H-indazol-4-yl)boronic acid HCl; 1-Methylindazole-4-boronic acid hydrochloride; 1-Methyl-4-boronoindazole hydrochloride; 4-(1-Methyl-1H-indazolyl)boronic acid hydrochloride; B-(1-Methyl-1H-indazol-4-yl)boronic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Methyl-1H-Indazole-4-Boronic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	95.0% - 105.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.