Description

7-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoquinolin-1-Amine is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. This compound is valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily sought after by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in constructing complex heterocyclic cores for oncology and CNS-targeted therapies.
• Agrochemical Research: Used to create new active ingredients for crop protection agents, leveraging its isoquinoline scaffold for bioactivity.
• Material Science: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Synthesis: An essential reagent in palladium-catalyzed cross-coupling reactions (Suzuki-Miyaura) for carbon-carbon bond formation under mild conditions.
• Academic & R&D: A valuable tool for medicinal chemistry and synthetic methodology research in university and corporate laboratories.

Basic Information

Product Name	7-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoquinolin-1-Amine
CAS No.	1257378-89-4
Molecular Formula	C₁₆H₂₃BN₂O₂
Molecular Weight	286.18 g/mol
Synonyms	1-Isoquinolinamine, 7-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 7-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1-amine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-7-methylisoquinolin-1-amine; 7-Methyl-1-aminoisoquinoline-4-boronic acid pinacol ester; 1-Amino-7-methylisoquinoline-4-boronic acid pinacol ester; B-7-Methyl-1-aminoisoquinolin-4-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 7-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoquinolin-1-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Assay	≥95.0% (by NMR)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.