Description

6-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1-amine is a high-purity, advanced pharmaceutical intermediate featuring a reactive boronic ester pinacol group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl structures in drug discovery pipelines.
• Pharmaceutical Intermediate: Serves as a versatile building block in the synthesis of potential therapeutic agents, particularly in oncology and CNS research.
• Chemical Biology & Proteomics: Used in the development of chemical probes and affinity tags for target identification and validation studies.
• Material Science Research: Employed in the synthesis of organic electronic materials and ligands for catalytic systems.
• Agrochemical Development: Acts as an intermediate in the research and synthesis of novel crop protection agents.

Basic Information

Product Name	6-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1-amine
CAS No.	1257378-82-7
Molecular Formula	C₁₅H₂₀BFN₂O₂
Molecular Weight	290.15 g/mol
Synonyms	1-Amino-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline; 6-Fluoro-1-isoquinolinamine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-fluoroisoquinolin-1-amine; 6-Fluoro-4-(pinacolatoboryl)isoquinolin-1-amine; 6-Fluoro-4-BPin-isoquinolin-1-amine; 1257378-82-7; 6-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isoquinolinamine
EINECS	Contact for details

Quality Control

Our 6-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1-amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.