Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoquinolin-1-Amine is a high-value, advanced pharmaceutical intermediate and building block in organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs) and functional materials, particularly through Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries seeking to incorporate complex heterocyclic and boronic ester functionalities into their target molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing potential drug candidates, especially in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to construct complex biaryl and heterobiaryl structures in medicinal chemistry.
• Agrochemical Research: Used in the development of new pesticides and herbicides with novel modes of action.
• Material Science: Serves as a precursor for organic electronic materials, such as OLED emitters and charge transport layers.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Academic & Contract Research: Essential reagent for synthetic organic chemistry research in universities and CROs.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoquinolin-1-Amine
CAS No.	1257296-47-1
Molecular Formula	C₁₅H₂₁BN₂O₂
Molecular Weight	272.15 g/mol
Synonyms	1-Amino-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-isoquinolinamine; 1-Isoquinolinamine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-Pinacolatoboryl-1-aminoisoquinoline; 4-Boronic acid, isoquinolin-1-amine, pinacol ester; 1257296-47-1
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoquinolin-1-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.