Description

2-(4-(Benzyloxy)-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its core value lies in enabling efficient and selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality reagents for drug discovery and fine chemical synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between aryl or vinyl boronic esters and organic halides, a cornerstone of medicinal chemistry.
• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl structures.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science & OLED Development: Employed in the synthesis of organic semiconductors, liquid crystals, and light-emitting materials for electronic devices.
• Chemical Biology & Probe Development: Facilitates the labeling and modification of biomolecules for research and diagnostic applications.
• Scale-up Process Chemistry: Suitable for transition from laboratory-scale research to pilot plant and commercial manufacturing due to its stability and reactivity profile.

Basic Information

Product Name	2-(4-(Benzyloxy)-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1257078-80-0
Molecular Formula	C20H25BO3
Molecular Weight	324.22 g/mol
Synonyms	3-Methyl-4-(benzyloxy)phenylboronic acid pinacol ester; 4-(Benzyloxy)-3-methylbenzeneboronic acid pinacol ester; (4-(Benzyloxy)-3-methylphenyl)boronic acid pinacol ester; 2-[4-(Phenylmethoxy)-3-methylphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; B-(4-(Benzyloxy)-3-methylphenyl)boronic acid pinacol ester; Pinacol (4-(benzyloxy)-3-methylphenyl)boronate
EINECS	Contact for details

Quality Control

Every batch of 2-(4-(Benzyloxy)-3-Methylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis and maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.