Description

5-Bromo-2-Fluoronicotinonitrile is a versatile and high-value halogenated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its molecular structure, featuring bromine and fluorine substituents on the pyridine ring, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Development: Used in the research and production of advanced pesticides and herbicides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Material Science: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce the bromo-fluoropyridine moiety into more complex molecular architectures.
• Life Science Research: Utilized as a biochemical probe or a tagged molecule in medicinal chemistry and diagnostic assay development.

Basic Information

Product Name	5-Bromo-2-Fluoronicotinonitrile
CAS No.	1256821-83-6
Molecular Formula	C6H2BrFN2
Molecular Weight	201.00 g/mol
Synonyms	2-Fluoro-5-bromonicotinonitrile; 5-Bromo-2-fluoropyridine-3-carbonitrile; 3-Cyano-5-bromo-2-fluoropyridine; Nicotinonitrile, 5-bromo-2-fluoro-; 2-Fluoro-5-bromo-3-cyanopyridine
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Fluoronicotinonitrile is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and GC-MS analysis, to ensure compliance with industry standards and customer-specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.