Description

Methyl 5-Bromo-4-Chloronicotinate is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound is valued for its reactive halogen substituents, which enable precise functionalization and the construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of nicotinic acid derivatives and other nitrogen-containing heterocycles with potential biological activity.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science: Serves as a precursor for the creation of specialized ligands, organic semiconductors, and liquid crystal compounds.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the presence of bromo and chloro leaving groups.
• Chemical Biology: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.
• Custom Synthesis: Provides a versatile starting point for contract research organizations (CROs) and fine chemical manufacturers producing tailored compounds.

Basic Information

Product Name	Methyl 5-Bromo-4-Chloronicotinate
CAS No.	1256808-62-4
Molecular Formula	C7H5BrClNO2
Molecular Weight	250.48 g/mol
Synonyms	5-Bromo-4-chloronicotinic acid methyl ester; Methyl 5-bromo-4-chloropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 5-bromo-4-chloro-, methyl ester; 5-Bromo-4-chloro-3-pyridinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-4-Chloronicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.