Description

3-Chloro-5-(Trifluoromethyl)Isonicotinaldehyde is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. Its unique structure, featuring both a reactive aldehyde group and a halogenated pyridine core, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethylpyridine moiety.
• Material Science Research: Serves as a precursor for designing novel ligands, functional polymers, and liquid crystals due to its rigid aromatic structure and modifiable functional groups.
• Cross-Coupling Reactions: The chloro substituent makes it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl systems.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening for generating diverse compound libraries in medicinal chemistry programs.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethyl)Isonicotinaldehyde
CAS No.	1256787-48-0
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	3-Chloro-5-(trifluoromethyl)pyridine-4-carbaldehyde; 4-Pyridinecarboxaldehyde, 3-chloro-5-(trifluoromethyl)-; 3-Chloro-5-trifluoromethylisonicotinaldehyde; 3-Chloro-5-(trifluoromethyl)-4-pyridinecarboxaldehyde; 3-Chloro-5-(trifluoromethyl)pyridine-4-carboxaldehyde; 3-Chloro-5-(trifluoromethyl)isonicotinaldehyde; 3-Chloro-5-(trifluoromethyl)-4-formylpyridine
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-5-(Trifluoromethyl)Isonicotinaldehyde is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable supply for critical research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.