Description

2-(2-Chloro-3,5-Dimethylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value, organoboron building block essential for modern synthetic chemistry. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl structures.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific chlorinated dimethylphenyl motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to synthesize boron-containing molecules used as probes and tools in biochemical and cellular studies.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the global life sciences industry.

Basic Information

Item	Details
Product Name	2-(2-Chloro-3,5-Dimethylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1256781-74-4
Molecular Formula	C₁₄H₂₀BClO₂
Molecular Weight	266.57 g/mol
Synonyms	2-(2-Chloro-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Chloro-3,5-dimethylphenyl)boronic acid pinacol ester; 2-Chloro-3,5-dimethylbenzeneboronic acid pinacol ester; Pinacol (2-chloro-3,5-dimethylphenyl)boronate; 2-Chloro-3,5-dimethylphenylboronic acid pinacol ester; 1256781-74-4; B-(2-Chloro-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of our 2-(2-Chloro-3,5-Dimethylphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured and tested under strict quality management systems. We guarantee high chemical purity and consistency, with specifications typically meeting or exceeding 97% (HPLC) purity for standard research grades. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles by NMR, HPLC, and GC are provided with each shipment to ensure traceability and support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry, and well-ventilated place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will compromise purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.