Description

2-Chloro-5-Methoxyphenylboronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific chlorinated and methoxylated phenyl structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers for OLEDs or OFETs, where precise molecular control is necessary.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs serving the global life sciences market.

Basic Information

Product Name	2-Chloro-5-Methoxyphenylboronic Acid Pinacol Ester
CAS No.	1256781-73-3
Molecular Formula	C₁₃H₁₈BClO₃
Molecular Weight	268.54 g/mol
Synonyms	2-Chloro-5-methoxyphenylboronic acid pinacol ester; (2-Chloro-5-methoxyphenyl)boronic acid pinacol ester; 2-Chloro-5-methoxybenzeneboronic acid pinacol ester; 4-Chloro-3-methoxyphenylboronic acid pinacol ester; (4-Chloro-3-methoxyphenyl)boronic acid pinacol ester; B-(2-Chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Chloro-5-methoxybenzeneboronic acid, pinacol ester; Pinacol (2-chloro-5-methoxyphenyl)boronate
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Methoxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) documenting purity, assay, and impurity profiles are available for every lot and provided upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.