Description

5-Hydroxy-2-Iodophenylboronic Acid Pinacol Ester is a sophisticated organoboron building block, specifically a protected boronic acid derivative, designed for advanced synthetic chemistry. Its core value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in pharmaceutical R&D, agrochemical discovery, and materials science, where it serves as a key intermediate for creating novel active ingredients and functional molecules. The pinacol ester protection enhances stability, offering superior handling and shelf-life compared to the free boronic acid.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific halogenated biphenyl structures.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of advanced organic electronic materials, such as OLEDs and conductive polymers.
• Ligand and Catalyst Development: Employed in the construction of novel bidentate or polydentate ligands for transition metal catalysis.
• Chemical Biology Probe Synthesis: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Academic and Contract Research: A valuable reagent for methodology development and complex molecule synthesis in academic and industrial research laboratories.

Basic Information

Product Name	5-Hydroxy-2-Iodophenylboronic Acid Pinacol Ester
CAS No.	1256781-71-1
Molecular Formula	C12H16BIO3
Molecular Weight	346.0 g/mol
Synonyms	2-Iodo-5-hydroxyphenylboronic acid pinacol ester; (5-Hydroxy-2-iodophenyl)boronic acid pinacol ester; 5-Hydroxy-2-iodobenzeneboronic acid pinacol ester; Pinacol (5-hydroxy-2-iodophenyl)boronate; 2-Iodo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; B-(5-Hydroxy-2-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 5-Hydroxy-2-Iodophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥95% (HPLC). Each lot is characterized by NMR (1H, 13C), mass spectrometry, and HPLC analysis to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and light-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.