Description

2-(3-Bromo-4-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical organoboron building block in modern synthetic chemistry. Its core value lies in enabling efficient, selective carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in constructing biaryl and heterobiaryl scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific halogenated phenyl structures.
• Material Science Research: Serves as a precursor in the development of organic light-emitting diodes (OLEDs), liquid crystals, and conductive polymers.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura couplings to introduce the 3-bromo-4-chlorophenyl moiety into target molecules.
• Chemical Synthesis: A versatile reagent for synthesizing complex organic molecules in academic and industrial R&D laboratories.
• Ligand and Catalyst Development: Used as a starting material for creating novel bidentate ligands and organometallic catalysts.

Basic Information

Product Name	2-(3-Bromo-4-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1256781-68-6
Molecular Formula	C12H15BBrClO2
Molecular Weight	316.41 g/mol
Synonyms	(3-Bromo-4-chlorophenyl)boronic acid pinacol ester; (3-Bromo-4-chlorophenyl)boronic acid, pinacol ester; 4-Chloro-3-bromophenylboronic acid pinacol ester; 2-(3-Bromo-4-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Bromo-4-chlorobenzeneboronic acid pinacol ester; Pinacol (3-bromo-4-chlorophenyl)boronate; B-(3-Bromo-4-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(3-Bromo-4-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR (¹H and ¹³C), and GC-MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maximize shelf-life stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.