Description

8-Fluoro-1,4-Dioxaspiro[4.5]Decane-8-Methanol is a high-value fluorinated spirocyclic building block, essential for introducing structural complexity and fluorine atoms into advanced molecular architectures. Its unique scaffold is critical for modulating the physicochemical properties, metabolic stability, and bioavailability of target compounds in pharmaceutical research. This intermediate is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides, where the fluorine atom enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for specialty monomers or additives in the development of advanced polymers with tailored properties.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes for studying enzyme mechanisms and biological pathways.
• Process Chemistry: Utilized in route scouting and optimization for the scalable production of complex fluorinated molecules.
• Academic Research: A valuable compound for methodological studies in organic synthesis, particularly in spirocycle formation and fluorination chemistry.

Basic Information

Product Name	8-Fluoro-1,4-Dioxaspiro[4.5]Decane-8-Methanol
CAS No.	1256545-97-7
Molecular Formula	C9H15FO3
Molecular Weight	190.21 g/mol
Synonyms	8-Fluoro-1,4-dioxaspiro[4.5]decan-8-ylmethanol; 8-(Hydroxymethyl)-8-fluoro-1,4-dioxaspiro[4.5]decane; 8-Fluoro-8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decane; Fluorinated Spiroketal Alcohol; 8-Fluoro-1,4-dioxaspiro[4.5]decane-8-methanol; 8-Fluoro-8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our 8-Fluoro-1,4-Dioxaspiro[4.5]Decane-8-Methanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity building blocks for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.