Description

1-(4,5-Difluoro-2-Methoxy-Phenyl)-Ethanone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industries requiring precise fluorination and methoxy-substituted aromatic scaffolds need this material for research and production.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and other therapeutic areas requiring fluorinated motifs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the difluoro-methoxy phenyl group can enhance biological activity and environmental stability.
• Material Science Research: Serves as a building block for creating specialized polymers, liquid crystals, or organic electronic materials that benefit from its specific electronic properties.
• Organic Synthesis & Catalysis: Employed in cross-coupling reactions, carbonyl chemistry, and as a substrate for developing new fluorination methodologies in academic and industrial R&D.
• Dye & Pigment Intermediate: Can be utilized in the synthesis of advanced fluorinated dyes and pigments for high-performance applications.

Basic Information

Product Name	1-(4,5-Difluoro-2-Methoxy-Phenyl)-Ethanone
CAS No.	1256477-94-7
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	4',5'-Difluoro-2'-Methoxyacetophenone; 2-Methoxy-4,5-difluoroacetophenone; 1-(4,5-Difluoro-2-methoxyphenyl)ethan-1-one; 4,5-Difluoro-2-methoxyacetophenone; Ethanone, 1-(4,5-difluoro-2-methoxyphenyl)-; 2'-Methoxy-4',5'-difluoroacetophenone; Acetophenone, 4,5-difluoro-2-methoxy-
EINECS	Contact for details

Quality Control

Our 1-(4,5-Difluoro-2-Methoxy-Phenyl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.