Description

2,2,2-Trifluoro-1-(5-Fluoro-2-Methoxyphenyl)Ethanone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its precise molecular architecture, featuring strategically placed fluorine and methoxy substituents, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials where fluorine incorporation is desired to modulate bioavailability, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving charge transport and stability.
• Advanced Polymer Chemistry: Employed to introduce fluorinated phenyl ketone moieties into polymer backbones, yielding materials with unique thermal, chemical, and surface properties.
• Chemical Research & Development: A valuable reagent for method development in cross-coupling reactions, fluorination chemistry, and the synthesis of complex heterocycles in academic and industrial R&D labs.
• Fluorinated Dye & Pigment Intermediate: Utilized in the synthesis of specialty dyes and pigments that require fluorinated aromatic segments for enhanced light fastness and color performance.

Basic Information

Product Name	2,2,2-Trifluoro-1-(5-Fluoro-2-Methoxyphenyl)Ethanone
CAS No.	1256467-37-4
Molecular Formula	C9H6F4O2
Molecular Weight	222.14 g/mol
Synonyms	5'-Fluoro-2'-methoxy-2,2,2-trifluoroacetophenone; 1-(5-Fluoro-2-methoxyphenyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-fluoro-2-methoxyphenyl)ethan-1-one; α,α,α-Trifluoro-5'-fluoro-2'-methoxyacetophenone; 5-Fluoro-2-methoxy-α,α,α-trifluoroacetophenone; TFMPA-F-OMe derivative; Trifluoromethyl ketone fluoromethoxy phenyl derivative
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(5-Fluoro-2-Methoxyphenyl)Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical and advanced material research. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), related substances, and residual solvents are provided with each shipment. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.