Description

n-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Cyclohexanamine is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the efficient synthesis of novel active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates requiring biaryl or heterobiaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between its aryl boronate group and various organic halides, facilitating the synthesis of complex molecular architectures.
• Agrochemical Synthesis: Used in the discovery and production of advanced herbicides, fungicides, and insecticides where specific fluorinated biaryl structures are desired.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs or organic photovoltaics, due to its functionalized aromatic core.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for diagnostic and biochemical research applications.

Basic Information

Product Name	n-(4-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Cyclohexanamine
CAS No.	1256360-60-7
Molecular Formula	C19H29BFNO2
Molecular Weight	333.25 g/mol
Synonyms	N-[(4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]cyclohexanamine; 2-(2-(((Cyclohexylamino)methyl)-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Cyclohexanamine, N-[(4-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]-; (4-Fluoro-2-(N-cyclohexylaminomethyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.