Description

n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Cyclopentanamine is a specialized boronic ester derivative, a crucial intermediate in modern synthetic organic chemistry and pharmaceutical research. Its core value lies in its role as a protected boronic acid, enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions under mild conditions. This high-purity building block is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as a stable, air-handleable precursor for introducing the cyclopentanamine-benzyl moiety into complex molecules for structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Intermediate in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a precursor for creating novel bidentate ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: Used in the synthesis of organic semiconductors, liquid crystals, and polymers with tailored electronic or photophysical properties.
• Chemical Biology Probes: Enables the labeling and study of biological targets through incorporation into activity-based probes and bioconjugates.

Basic Information

Product Name	n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Cyclopentanamine
CAS No.	1256360-57-2
Molecular Formula	C18H28BNO2
Molecular Weight	301.24 g/mol
Synonyms	N-[(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]cyclopentanamine; Cyclopentanamine, N-[[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]-; 2-(Aminomethyl)phenylboronic acid pinacol ester (cyclopentyl derivative); N-(2-Pinacolatoborylbenzyl)cyclopentanamine; (2-((Cyclopentylamino)methyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)Cyclopentanamine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We adhere to cGMP principles for advanced intermediates, ensuring traceability and documentation suitable for pre-clinical and early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.