Description

2-(4-(Bromomethyl)-2-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a pinacol boronic ester, designed for advanced synthetic chemistry. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heteroaryl structures. It is an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific halogenated aryl structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for diagnostic and research applications.
• Catalyst & Ligand Development: A valuable starting material for synthesizing novel ligands and catalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research laboratories for custom synthesis projects and process development.

Basic Information

Product Name	2-(4-(Bromomethyl)-2-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1256360-55-0
Molecular Formula	C13H17BBrClO2
Molecular Weight	334.44 g/mol
Synonyms	2-Chloro-4-(bromomethyl)phenylboronic acid pinacol ester; (4-(Bromomethyl)-2-chlorophenyl)boronic acid pinacol ester; 1-(Bromomethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chlorobenzene; 2-(4-(Bromomethyl)-2-chlorophenyl)-1,3,2-dioxaborolane, 4,4,5,5-tetramethyl-; Pinacol (4-(bromomethyl)-2-chlorophenyl)boronate; 2-Chloro-4-bromomethylbenzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(4-(Bromomethyl)-2-Chlorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high purity and consistent performance for critical coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.