Description

n-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)-2-Methylpropan-2-Amine is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, which is critical for modern cross-coupling reactions in synthetic chemistry. This compound is essential for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas. Its primary value lies in enabling efficient, late-stage functionalization and the construction of complex molecular architectures, making it indispensable for medicinal chemistry and process R&D laboratories globally.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for constructing biaryl and heterobiaryl scaffolds in drug discovery.
• Pharmaceutical Intermediate: Used in the synthesis of complex target molecules for potential therapeutics in oncology, neurology, and immunology.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization by providing a versatile handle for molecular diversification.
• Process Chemistry Development: Employed in route scouting and scale-up synthesis for the manufacturing of Active Pharmaceutical Ingredients (APIs).
• Agrochemical Research: Can be utilized in the synthesis of novel compounds for crop protection and agrochemical development.
• Material Science Precursor: Acts as a building block for organic electronic materials and functional polymers.

Basic Information

Product Name	n-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)-2-Methylpropan-2-Amine
CAS No.	1256360-52-7
Molecular Formula	C₁₇H₂₇BFNO₂
Molecular Weight	307.21 g/mol
Synonyms	2-Methyl-N-[(2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]propan-2-amine; 2-Fluoro-3-((tert-butylamino)methyl)phenylboronic acid pinacol ester; 2-Fluoro-3-((tert-butylaminomethyl)phenylboronic acid pinacol ester; tert-Butyl-[2-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-amine; (2-Fluoro-3-((tert-butylamino)methyl)phenyl)boronic acid pinacol ester; 1256360-52-7; N-(2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-2-methylpropan-2-amine
EINECS	Contact for details

Quality Control

Our n-(2-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzyl)-2-Methylpropan-2-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended long-term storage temperature is between 2°C and 8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.