Description

3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6,7,8-Tetrahydroquinoline is a high-purity, advanced pharmaceutical intermediate and a versatile boronic ester building block. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in pharmaceutical R&D, agrochemical synthesis, and materials science who require reliable, high-quality coupling partners for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing the tetrahydroquinoline scaffold.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical organoboron reagent for palladium-catalyzed carbon-carbon bond formation, enabling the construction of complex molecular architectures.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that incorporate the quinoline moiety.
• Material Science & OLED Development: A precursor for creating organic electronic materials, including charge-transport layers and emissive materials in OLED devices.
• Ligand Synthesis: Utilized in the preparation of novel nitrogen-containing ligands for catalysis.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological systems and target engagement.

Basic Information

Item	Details
Product Name	3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6,7,8-Tetrahydroquinoline
CAS No.	1256360-50-5
Molecular Formula	C15H22BNO2
Molecular Weight	259.15 g/mol
Synonyms	5,6,7,8-Tetrahydroquinolin-3-ylboronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydroquinoline; 3-Tetrahydroquinolinylboronic acid pinacol ester; 3-Boronic acid, 5,6,7,8-tetrahydroquinolin-3-yl-, pinacol ester; 3-(Pinacolatoboryl)-5,6,7,8-tetrahydroquinoline; 3-Quinolinylboronic acid, 5,6,7,8-tetrahydro-, pinacol ester
EINECS	Contact for details

Quality Control

Our 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5,6,7,8-Tetrahydroquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with REACH, TSCA, and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and during weighing to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.