Description

2-Bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to develop novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing trifluoromethylpyridine and aryl-boronate motifs.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Used in the development of organic electronic materials, such as OLED emitters and charge-transport layers.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in homogeneous catalysis.
• Chemical Biology Probes: Employed in the creation of molecular probes and tags for studying biological systems.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the life sciences industry.

Basic Information

Product Name	2-Bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine
CAS No.	1256360-49-2
Molecular Formula	C12H14BBrF3NO2
Molecular Weight	336.96 g/mol
Synonyms	2-Bromo-6-(trifluoromethyl)pyridine-4-boronic acid pinacol ester; 2-Bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine; 4-Bromo-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine; 2-Bromo-4-(pinacolatoboryl)-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-2-bromopyridine-4-boronic acid pinacol ester; Pyridine, 2-bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, supporting your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature is 2-8°C for extended periods; allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.