Description

1-(3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarbonitrile is a high-value, multi-functional boronic ester pinacol ester intermediate designed for advanced organic synthesis. Its molecular architecture, featuring both a reactive boronate ester and a nitrile-substituted cyclopropane, makes it an essential building block for constructing complex molecules. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key aryl boronate ester coupling partner for the synthesis of biaryl structures, a common motif in active pharmaceutical ingredients (APIs).
• Medicinal Chemistry & Drug Discovery: Used as a versatile intermediate in the research and development of new drug candidates, particularly for constructing complex, sterically hindered molecular scaffolds.
• Agrochemical Synthesis: Employed in the creation of novel herbicides, fungicides, and insecticides that require specific halogenated and functionalized aromatic systems.
• Material Science & OLED Development: Acts as a precursor for synthesizing organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Utilized to create tagged molecules and chemical probes for studying biological pathways and protein interactions.

Basic Information

Product Name	1-(3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarbonitrile
CAS No.	1256360-48-1
Molecular Formula	C16H19BClNO2
Molecular Weight	303.59 g/mol
Synonyms	[3-Chloro-5-(1-cyanocyclopropyl)phenyl]boronic acid pinacol ester; 1-[3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropanecarbonitrile; 3-Chloro-5-(1-cyanocyclopropyl)phenylboronic acid pinacol ester; (3-Chloro-5-(1-cyanocyclopropyl)phenyl)boronic acid pinacol ester; 1-(3-Chloro-5-(pinacolboranyl)phenyl)cyclopropanecarbonitrile; Boronic acid, B-[3-chloro-5-(1-cyanocyclopropyl)phenyl]-, pinacol ester; CAS 1256360-48-1
EINECS	Contact for details

Quality Control

Our production of 1-(3-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropanecarbonitrile adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including NMR (1H, 13C, 11B), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.