Description

5-Bromo-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for drug discovery, ligand synthesis, and the development of functional organic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing complex pyridine and heterocyclic cores.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific halogenated and borylated pyridine structures.
• Material Science & OLED Development: Serves as a building block for creating organic light-emitting diode (OLED) materials, ligands for catalysts, and other functional organic electronic components.
• Cross-Coupling Reactions (Suzuki-Miyaura): The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed cross-coupling with various aryl/heteroaryl halides, enabling efficient carbon-carbon bond formation.
• Chemical Research & Library Synthesis: Employed in medicinal and combinatorial chemistry for the rapid generation of diverse compound libraries for high-throughput screening.
• Ligand and Catalyst Preparation: Useful in the synthesis of novel bidentate or polydentate ligands for transition metal catalysis.

Basic Information

Product Name	5-Bromo-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine
CAS No.	1256360-43-6
Molecular Formula	C₁₂H₁₇BBrNO₂
Molecular Weight	298.99 g/mol
Synonyms	3-Bromo-6-methyl-2-pyridinylboronic acid pinacol ester; 5-Bromo-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Methyl-5-bromo-3-pyridineboronic acid pinacol ester; (5-Bromo-2-methylpyridin-3-yl)boronic acid pinacol ester; 5-Bromo-2-methylpyridine-3-boronic acid pinacol ester; Pinacol (5-bromo-2-methyl-3-pyridyl)boronate
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Methyl-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with the standards demanded by cGMP and ISO-guided facilities for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.