Description

4-Chloro-1-Methylindole-2-Boronic Acid, Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its primary value lies in enabling the efficient and precise construction of complex indole-based molecular architectures, which are core scaffolds in numerous active compounds. This advanced intermediate is critically needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel drug candidates, crop protection agents, and functional organic molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel indole-based drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the indole structure for biological activity.
• Material Science: Serves as a building block for creating organic electronic materials, such as OLEDs and semiconductors, due to its conjugated system.
• Chemical Biology: Employed in the synthesis of molecular probes and labeled compounds for biochemical and pharmacological studies.
• Catalyst & Ligand Development: Utilized in the preparation of specialized ligands for transition metal catalysis.
• Academic & Contract Research: A vital reagent for methodology development and complex molecule synthesis in academic and industrial R&D laboratories.

Basic Information

Product Name	4-Chloro-1-Methylindole-2-Boronic Acid, Pinacol Ester
CAS No.	1256360-42-5
Molecular Formula	C₁₅H₁₉BClNO₂
Molecular Weight	291.58 g/mol
Synonyms	4-Chloro-1-methyl-1H-indole-2-boronic acid pinacol ester; 1-Methyl-4-chloroindole-2-boronic acid pinacol ester; (4-Chloro-1-methyl-1H-indol-2-yl)boronic acid pinacol ester; 4-Chloro-1-methylindole-2-boronic acid neopentyl glycol ester (common alternative); B-(4-Chloro-1-methyl-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (4-chloro-1-methyl-1H-indol-2-yl)boronate; CAS 1256360-42-5
EINECS	Contact for details

Quality Control

Our 4-Chloro-1-Methylindole-2-Boronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production use. All materials are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.