Description

2-(3-(Bromomethyl)-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value, multi-functional organoboron building block, essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is critically needed by R&D and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The primary application, facilitating the efficient and selective formation of biaryl and heterobiaryl structures.
• Chemical Biology Probes: Enables the synthesis of tagged molecules for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial manufacturing of fine chemicals.

Basic Information

Product Name	2-(3-(Bromomethyl)-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1256360-37-8
Molecular Formula	C₁₃H₁₇BBrFO₂
Molecular Weight	329.99 g/mol
Synonyms	2-(3-(Bromomethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3-(Bromomethyl)-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-3-(bromomethyl)phenylboronic acid pinacol ester; 1-Bromo-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylbenzene; 3-Bromomethyl-2-fluorophenylboronic acid pinacol ester; Pinacol [3-(bromomethyl)-2-fluorophenyl]boronate
EINECS	Contact for details

Quality Control

Our 2-(3-(Bromomethyl)-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.