Description

2,4-Dichloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is a high-value, multi-functional chemical intermediate that combines a phenolic core with a boronic ester protecting group. This compound matters for its role as a versatile building block in modern synthetic chemistry, enabling precise carbon-carbon bond formation. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing a substituted phenol or biphenyl moiety.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the 2,4-dichlorophenol structure is pharmacologically relevant.
• Material Science: Serves as a monomer or cross-linking agent in the development of advanced polymers, resins, and functional organic materials.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed coupling with aryl or vinyl halides, a cornerstone reaction in medicinal and process chemistry.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands or metal-organic frameworks (MOFs) due to its phenolic and boronic ester functionalities.
• Chemical Research: Employed in academic and industrial laboratories for method development and exploring new synthetic pathways.

Basic Information

Item	Details
Product Name	2,4-Dichloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol
CAS No.	1256360-32-3
Molecular Formula	C12H15BCl2O3
Molecular Weight	289.96 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,4-dichlorophenol; 2,4-Dichloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 2,4-Dichlorophenylboronic acid pinacol ester; (2,4-Dichloro-5-hydroxyphenyl)boronic acid pinacol ester; 2,4-Dichloro-5-pinacolatoborylphenol; Boronic acid, B-(2,4-dichloro-5-hydroxyphenyl)-, 1,1-dimethylethyl ester; 1256360-32-3
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance for critical coupling reactions. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature and susceptibility to oxidation, it is recommended to handle and store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.