Description

1-(Tetrahydro-2H-Pyran-2-Yl)-3,5-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, multi-functional boronic ester derivative designed for advanced synthetic chemistry. This compound serves as a critical protected pyrazole building block, offering two reactive boronate sites for sequential cross-coupling reactions. It is essential for researchers and process chemists in pharmaceutical development and agrochemical synthesis who require precise, modular construction of complex heterocyclic targets.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Enables the efficient, palladium-catalyzed formation of carbon-carbon bonds to construct complex biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides with pyrazole-based active components.
• Material Science: Serves as a monomer or functional unit in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Facilitates the modular assembly of bifunctional molecules for targeted protein degradation studies.
• Library Synthesis for Drug Discovery: Ideal for generating diverse compound libraries via parallel synthesis for high-throughput screening (HTS).

Basic Information

Item	Detail
Product Name	1-(Tetrahydro-2H-Pyran-2-Yl)-3,5-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1256360-29-8
Molecular Formula	C22H38B2N2O5
Molecular Weight	440.17 g/mol
Synonyms	3,5-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole; 1-THP-3,5-bis(pinacolboronate)pyrazole; 1-(Tetrahydropyran-2-yl)-3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 3,5-Diboronic acid pinacol ester pyrazole THP-protected; Pyrazole-3,5-diboronic acid bis(pinacol ester) N-THP protected; 1-(Oxan-2-yl)-3,5-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
EINECS	Contact for details

Quality Control

Our 1-(Tetrahydro-2H-Pyran-2-Yl)-3,5-Bis(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.