Description

n-(2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanesulfonamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly those requiring biaryl linkages for target binding.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aromatic rings under mild conditions, essential for constructing diverse chemical libraries.
• Medicinal Chemistry Research: Used in the discovery and optimization phase for new therapeutic agents in oncology, CNS disorders, and infectious diseases.
• Agrochemical Synthesis: Serves as an intermediate in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and advanced polymers requiring specific aromatic architectures.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	n-(2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanesulfonamide
CAS No.	1256360-27-6
Molecular Formula	C14H22BNO5S
Molecular Weight	327.20 g/mol
Synonyms	2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(methylsulfonyl)aniline; Methanesulfonamide, N-[2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxybenzenesulfonamide derivative; Pinacol ester of [2-Methoxy-5-(methanesulfonamido)phenyl]boronic acid; B-[2-Methoxy-5-[(methylsulfonyl)amino]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our n-(2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Methanesulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP compliance for use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.