Description

2-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its primary commercial value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and advanced materials synthesis. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries seeking to construct complex biaryl and heterobiaryl structures with precision.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and chlorinated biaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific halogenated aromatic frameworks.
• Material Science: Serves as a monomer or precursor in the development of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs).
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on palladium-catalyzed cross-coupling methodologies.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	2-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol
CAS No.	1256360-20-9
Molecular Formula	C12H15BClFO3
Molecular Weight	271.51 g/mol
Synonyms	2-Chloro-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 5-Boronic acid, 2-chloro-4-fluoro-, 1,3,2-dioxaborolane ester; 2-Chloro-4-fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; Phenol, 2-chloro-4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; (2-Chloro-4-fluoro-5-hydroxyphenyl)boronic acid pinacol ester; 2-Chloro-4-fluoro-5-pinacolatoboronphenol; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-4-fluorophenol
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation by NMR and IR spectroscopy to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.