Description

2-(4-Chloro-2-Fluoro-5-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex biaryl structures.
• Pharmaceutical Intermediate: Used in the research and production of active pharmaceutical ingredients (APIs), especially those containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Serves as a precursor in the manufacturing of advanced herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors.
• Chemical Biology & Medicinal Chemistry: Facilitates the creation of molecular probes and candidate drug molecules for biological screening.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific functionalized aromatic compounds.

Basic Information

Product Name	2-(4-Chloro-2-Fluoro-5-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1256360-16-3
Molecular Formula	C15H21BClFO3
Molecular Weight	314.59 g/mol
Synonyms	4-Chloro-2-fluoro-5-isopropoxyphenylboronic acid pinacol ester; (4-Chloro-2-fluoro-5-isopropoxyphenyl)boronic acid pinacol ester; 5-Isopropoxy-4-chloro-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-4-chloro-5-isopropoxyphenylboronic acid pinacol ester; Pinacol (4-chloro-2-fluoro-5-isopropoxyphenyl)boronate; CAS 1256360-16-3; Boronic ester intermediate 1256360-16-3
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Chloro-2-Fluoro-5-Isopropoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive cross-coupling applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and other relevant techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent moisture absorption and decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.