Description

1-(Methoxymethyl)-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction to construct complex molecular architectures. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds in complex organic synthesis.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic molecules.
• Bioconjugation & Probe Development: Facilitates the labeling and modification of biomolecules for diagnostic and research applications.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.
• Agrochemical Research: Employed in the development of novel crop protection agents and pesticides.
• Material Science: Potential use in the synthesis of organic electronic materials and polymers.

Basic Information

Product Name	1-(Methoxymethyl)-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole
CAS No.	1256360-14-1
Molecular Formula	C15H21BN2O3
Molecular Weight	288.15 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(methoxymethyl)-1H-indazole; 1H-Indazole, 1-(methoxymethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-Methoxymethyl-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole; 1-(Methoxymethyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole; Pinacol 1-(Methoxymethyl)-1H-indazol-6-ylboronate
EINECS	Contact for details

Quality Control

Our 1-(Methoxymethyl)-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.