Description

1-(Ethylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its unique structure, combining a pyrrole core with a sulfonyl and a pinacol boronate ester group, makes it a critical intermediate for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials. Its reliable performance under Suzuki-Miyaura and other palladium-catalyzed conditions makes it indispensable for efficient drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in constructing heterocyclic cores for kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, enabling the introduction of the pyrrole-sulfonyl pharmacophore.
• Material Science Research: Serves as a precursor for creating functional organic materials, such as organic semiconductors, conductive polymers, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura cross-coupling to form carbon-carbon bonds, facilitating the modular construction of complex biaryl and heterobiaryl structures.
• Chemical Biology & Probe Development: Utilized to create tagged molecules and chemical probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Provides a reliable and scalable intermediate for optimizing synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	1-(Ethylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole
CAS No.	1256360-10-7
Molecular Formula	C12H20BNO4S
Molecular Weight	285.17 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(ethylsulfonyl)-1H-pyrrole; 1H-Pyrrole, 1-(ethylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1-(Ethylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrole; 1-(Ethanesulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole; 3-Boronic acid, 1-(ethylsulfonyl)-1H-pyrrole-3-, pinacol ester; Pyrrole-3-boronic acid pinacol ester, 1-(ethylsulfonyl)- derivative
EINECS	Contact for details

Quality Control

Every batch of 1-(Ethylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole is manufactured and analyzed under strict quality management protocols to ensure consistency and reliability for critical R&D and scale-up applications. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with exacting industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.