Description

1-Boc-5-Methoxyindole-3-Boronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for facilitating efficient cross-coupling reactions, enabling the rapid construction of complex indole-based molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical boron-containing reagent for forming carbon-carbon bonds, essential for constructing complex heterocyclic compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with indole-based structures.
• Material Science: Employed in the creation of organic semiconductors, light-emitting diodes (OLEDs), and other functional organic materials.
• Academic & Contract Research: A valuable tool for synthetic organic chemists in universities and CROs (Contract Research Organizations) for methodological development and library synthesis.
• Peptidomimetics & Bioconjugation: Facilitates the synthesis of indole-containing peptidomimetics and bioconjugates for biochemical and diagnostic applications.

Basic Information

Product Name	1-Boc-5-Methoxyindole-3-Boronic Acid, Pinacol Ester
CAS No.	1256359-99-5
Molecular Formula	C20H28BNO5
Molecular Weight	373.25 g/mol
Synonyms	5-Methoxy-1-[(2-methylpropan-2-yl)oxycarbonyl]-1H-indole-3-boronic acid pinacol ester; 1-(tert-Butoxycarbonyl)-5-methoxyindole-3-boronic acid pinacol ester; 1-Boc-5-methoxy-1H-indole-3-boronic acid pinacol ester; tert-Butyl 5-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 5-Methoxy-1-Boc-indole-3-boronic acid pinacol ester; Boc-5-MeO-Indole-3-Bpin
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Methoxyindole-3-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications, and our quality commitment ensures reliable performance in your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.