Description

4-Fluoroindole-2-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound matters as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex fluorinated indole derivatives. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical synthon for constructing fluorinated indole scaffolds in drug discovery programs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel crop protection agents and herbicides with enhanced properties.
• Material Science Research: Serves as a precursor for creating specialized fluorinated polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The pinacol ester group provides enhanced stability, making it a preferred reagent for palladium-catalyzed C-C bond formation under mild conditions.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated molecular probes for studying biological processes and enzyme mechanisms.
• Library Synthesis for HTS: Enables the rapid generation of diverse compound libraries for high-throughput screening in lead identification.

Basic Information

Product Name	4-Fluoroindole-2-Boronic Acid Pinacol Ester
CAS No.	1256359-96-2
Molecular Formula	C₁₄H₁₇BFNO₂
Molecular Weight	261.10 g/mol
Synonyms	4-Fluoro-1H-indole-2-boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-fluoro-1H-indole; 4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 4-Fluoroindole-2-boronic acid, pinacol ester; 4-Fluoro-1H-indole-2-boronpinacol ester; B-(4-Fluoro-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4-Fluoroindole-2-Boronic Acid Pinacol Ester is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and LC-MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.