Description

1-Boc-4-Chloroindole-3-Boronic Acid, Pinacol Ester is a high-value, protected boronic acid ester derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling efficient, palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura couplings, to construct complex heterocyclic scaffolds. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals. The Boc-protected amine and chloro-substituted indole core provide orthogonal reactivity for precise molecular assembly.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel indole-based drug candidates, including kinase inhibitors, antiviral agents, and CNS-active compounds.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Material Science: Enables the synthesis of functional organic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers, via cross-coupling methodologies.
• Chemical Biology & Proteomics: Serves as a versatile handle for creating molecular probes, activity-based probes (ABPs), and bioconjugates for target identification and validation.
• Academic & Contract Research: A vital reagent for methodology development in organic synthesis and for constructing bespoke compound libraries for high-throughput screening.

Basic Information

Product Name	1-Boc-4-Chloroindole-3-Boronic Acid, Pinacol Ester
CAS No.	1256359-94-0
Molecular Formula	C19H25BClNO4
Molecular Weight	377.67 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-chloro-1H-indole-3-boronic acid pinacol ester; 4-Chloro-1-[(2-methylpropan-2-yl)oxycarbonyl]indole-3-boronic acid pinacol ester; tert-Butyl 4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1-Boc-4-chloroindole-3-boronic acid pinacol ester; 4-Chloro-1-Boc-indole-3-boronic acid pinacol ester; 1-Boc-4-Cl-indole-3-Bpin; BOC-4-Cl-Indole-3-Bpin
EINECS	Contact for details

Quality Control

Our 1-Boc-4-Chloroindole-3-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, and 11B where applicable), and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support cGMP-compliant production for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. For long-term storage, desiccants are recommended. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.